Thermo Fisher Scientific STAT6 Polyclonal Antibody
STAT6 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, ICC/IF, ELISA에 적합하며, 세포질 및 핵에서 STAT6 발현 검출에 활용됩니다. IL-4 관련 Th2 면역반응 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 501–600 of human STAT6 (NP_0031443) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.07 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804205 |
Product Specific Information
- Positive Samples: HeLa, Jurkat, A-431, THP-1
- Cellular Location: Cytoplasm, Nucleus
Immunogen sequence:
AACTCCTGCT AATGGGACTG GGCCAAGTGA GGCCCTGGCC ATGCTACTGC AGGAGACCAC TGGAGAGCTA GAGGCAGCCA AAGCCCTAGT GCTGAAGAGG
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 (IL-4) and IL-13. STAT6-deficient (Stat6-/-) cells lack IL-4-mediated functions such as Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4-mediated proliferation. STAT6 mRNA is expressed in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. STAT6 plays a crucial role in Th2 immune responses and exists in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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