Thermo Fisher Scientific ErbB4 Polyclonal Antibody
ErbB4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot과 ELISA에 적합하며, Rat 시료에서 반응. Affinity Chromatography로 정제된 액상 항체로, PBS/glycerol buffer에 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA587501
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ErbB4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1150–1250 of human ErbB4/HER4 (NP_005226.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.45 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804204 |
Product Specific Information
Immunogen sequence:
YMTPMRDKPK QEYLNPVEEN PFVSRRKNGD LQALDNPEYH NASNGPPKAE DEYVNEPLYL NTFANTLGKA EYLKNNILSM PEKAKKAFDN PDYWNHSLPP R
Positive Samples: Rat brain
Cellular Location: Cell membrane, mitochondrion, nucleus, single-pass type I membrane protein
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing various cellular responses such as mitogenesis and differentiation.
It acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation.
ErbB4 regulates key cellular processes including:
- Cellular metabolism
- Transcription
- Cell cycle progression
- Cytoskeletal rearrangement and movement
- Apoptosis and differentiation
Expression:
Highly expressed in several breast carcinoma cell lines (T47-D, MDA-MB-453, BT-474, H3396), and in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
Intermediate expression in MCF-7, MDA-MB-330, MDA-MB-361; low or absent in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ErbB4 levels have been found in certain human tumor cell lines, suggesting a role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.