Thermo Fisher Scientific NBS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 520-754 of human NBS1/NBN (NP_0024762) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NBS1,uniProtId:O60934-1,ncbiNodeId:9606,antigenRange:520-754,antigenLength:754,antigenImageFileName:PA5-87503_NBS1_O60934-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87503_NBS1_O60934-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804206

Product Specific Information

Immunogen sequence: NNLFTDTDLK SIVKNSASKS HAAEKLRSNK KREMDDVAIE DEVLEQLFKD TKPELEIDVK VQKQEEDVNV RKRPRMDIET NDTFSDEAVP ESSKISQENE IGKKRELKED SLWSAKEISN NDKLQDDSEM LPKKLLLTEF RSLVIKNSTS RNPSGINDDY GQLKNFKKFK KVTYPGAGKL PHIIGGSDLI AHHARKNTEL EEWLRQEMEV QNQHAKEESL ADDLFRYNPY LKRRR

Positive Samples: U-87MG, HeLa, HepG2, mouse liver; Cellular Location: Chromosome, Nucleus, PML body, telomere

Target Information

The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.