Thermo Fisher Scientific NBS1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal Antibody로, NBS1 단백질 검출에 사용. Western blot, IHC, ELISA 등 다양한 응용 가능. 고순도 Affinity Chromatography 정제, 안정적 PBS/glycerol buffer 보관.
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Thermo Fisher Scientific NBS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 520–754 of human NBS1/NBN (NP_0024762) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804206 |
Product Specific Information
Immunogen sequence:
NNLFTDTDLK SIVKNSASKS HAAEKLRSNK KREMDDVAIE DEVLEQLFKD TKPELEIDVK VQKQEEDVNV RKRPRMDIET NDTFSDEAVP ESSKISQENE IGKKRELKED SLWSAKEISN NDKLQDDSEM LPKKLLLTEF RSLVIKNSTS RNPSGINDDY GQLKNFKKFK KVTYPGAGKL PHIIGGSDLI AHHARKNTEL EEWLRQEMEV QNQHAKEESL ADDLFRYNPY LKRRR
Positive Samples: U-87MG, HeLa, HepG2, mouse liver
Cellular Location: Chromosome, Nucleus, PML body, telomere
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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