Thermo Fisher Scientific Phospho-ATM (Ser1981) Monoclonal Antibody (C.70.6)
Human ATM 단백질의 Ser1981 인산화 부위를 인식하는 mouse monoclonal antibody. Western blot, ICC/IF, ChIP에 적합. 액상 형태, 고농도(2028 µg/mL), -20°C 보관. DNA 손상 반응 및 세포주기 조절 연구에 활용 가능.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | 3 µL / 10⁶ cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.70.6 |
| Immunogen | Synthetic phosphopeptide corresponding to residues around pSer1981 of human ATM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2028 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10979447 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- Originally validated as part of a Thermo Scientific Cellomics High Content Screening Kit.
- When sold separately, performance may vary and require optimization for best results.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a member of the PI3/PI4 kinase family. The ATM gene encodes a protein that phosphorylates downstream targets such as P53, Mdm2, BRCA1, and SMC1, which regulate cell-cycle progression and DNA repair.
ATM is activated by ionizing radiation and other mutagens, leading to autophosphorylation and initiation of kinase cascades involved in DNA damage response, apoptosis, and cell-cycle control.
Defects in ATM cause ataxia-telangiectasia, characterized by neurological degeneration, immunodeficiency, and predisposition to lymphoid cancers.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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