Thermo Fisher Scientific Phospho-Girdin (Tyr1764) Polyclonal Antibody
Phospho-Girdin (Tyr1764) 특이적 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. EGF 및 Pervanadate 처리된 A431 세포에서 250 kDa 단백질을 검출합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5143704
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-Girdin (Tyr-1764) synthetic peptide (coupled to carrier) corresponding to amino acid residues around tyrosine 1764 in human Girdin. This sequence has high homology to rat and mouse Girdin, and the site is not conserved in other Girdin family members. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942932 |
Product Specific Information
The antibody was cross-absorbed to unphosphorylated Girdin (Tyr-1764) peptide before affinity purification using phospho-Girdin (Tyr-1764) peptide.
This antibody detects a 250 kDa protein on SDS-PAGE immunoblots of human A431 cells stimulated with EGF and Pervanadate.
These reactivities are not observed after alkaline phosphatase treatment to dephosphorylate Girdin.
Target Information
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis.
It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders.
DISC1 is thought to be involved in the migration, positioning, and differentiation of dentate granule cells (DGCs) during development.
Depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration or mispositioning of DGCs, suggesting that Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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