Thermo Fisher Scientific CD126 Monoclonal Antibody (D7715A7), PE, eBioscience
마우스 CD126(IL-6 receptor α chain)을 인식하는 단클론 항체로, PE 형광표지되어 있습니다. 유세포분석(Flow Cytometry)에 적합하며, 0.125 µg/test로 사용됩니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 0.125 µg/test
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Recommended Isotype Control | Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D7715A7 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_996658 |
Additional Formats:
Product Specific Information
The monoclonal antibody D7715A7 recognizes mouse CD126, the IL-6 receptor alpha chain, a member of the Ig superfamily. CD126 can heterodimerize with CD130 (gp130) to form the high affinity IL-6 receptor. Upon IL-6 binding, signaling from the CD130 subunit is initiated and the receptor complex is internalized.
A soluble version of the IL-6 receptor also exists, which, when bound to IL-6, acts in trans to signal. Expression is found on peripheral T lymphocytes and during thymic development is restricted to SP populations. Additional expression occurs on activated B lymphocytes, macrophages, granulocytes, and CD34⁺ hematopoietic progenitor cells. The D7715A7 binding can be blocked by the addition of IL-6 ligand.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of mouse splenocytes.
Recommended ≤ 0.125 µg per test (100 µL final volume).
Cell number: 10⁵–10⁸ cells/test (empirically determined).
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the IL-6 receptor complex. IL-6 regulates cell growth and differentiation and plays an essential role in immune response.
The IL6 receptor complex includes IL6ST/GP130, a receptor subunit shared by many cytokines. Dysregulated IL6 and IL6R expression are implicated in diseases such as multiple myeloma, autoimmune disorders, and prostate cancer. Alternatively spliced variants and a pseudogene on chromosome 9 have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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