Thermo Fisher Scientific JAM-A (CD321) Monoclonal Antibody (M.Ab.F11)
JAM-A(CD321)을 인식하는 Mouse IgG1 단클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 분석에 사용 가능. Human 시료에 반응하며, Protein G로 정제된 액상 형태. 세포 간 접착 및 tight junction 연구에 적합. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:50 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50 |
| Immunoprecipitation (IP) | 1:50 |
| Functional Assay (Functional) | 1:50 |
| Inhibition Assays (IA) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M.Ab.F11 |
| Immunogen | Human platelet membranes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_3091066 |
Product Specific Information
The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A), also known as the human platelet F11-Receptor (F11R) or JAM-1.
Target Information
CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. It is a 32–41 kDa glycoprotein with two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail. The protein forms homodimers and associates with other membrane proteins such as integrins.
CD321 is expressed on leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and mediates cell-cell contact. It is located near tight junction components including ZO-1 and occludin, and plays roles in maintaining epithelial/endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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