Thermo Fisher Scientific MUTYH Polyclonal Antibody
Human MUTYH 단백질을 인식하는 Goat Polyclonal Antibody로, Western blot에 0.1–0.3 µg/mL 농도로 사용 가능. 합성 펩타이드 면역원 기반, 액상 형태이며 TBS/BSA 버퍼에 보존. DNA 손상 복구 연구 및 산화 스트레스 관련 실험에 적합.
- 카탈로그번호
- PA518267
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 0.1–0.3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (HISTDAHSLNSAAQ) corresponding to the C-terminus amino acids of MUTYH (aa 533–546) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10981954 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
MYH (mutY homolog, E. coli) is a DNA glycosylase mismatch repair enzyme that, in conjunction with mutM (OGG1), cleaves adenine residues paired with oxidized or non-modified guanines to correct A/G and A/C mismatches.
DNA glycosylases initiate base excision repair by binding and cleaving N-glycosyl bonds. MYH is crucial for preventing mutations from oxidative DNA damage.
Multiple N-terminal splice variants of MYH exist in mammalian cells. Elevated MYH levels in A549 cells exposed to oxygen and infrared radiation improve cell survival.
Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, maintaining mitochondrial genome integrity against reactive oxygen species (ROS) throughout the mammalian lifespan.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-18267_MUTYH_Q9UIF7-1_Goat.svg
- PA5-18267_MUTYH_Q9UIF7-1_Goat_PDP.jpeg
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