Thermo Fisher Scientific MERTK Recombinant Rabbit Monoclonal Antibody (ARC0229)
Thermo Fisher의 MERTK Recombinant Rabbit Monoclonal Antibody (ARC0229)은 인간 MERTK 단백질을 인식하는 고특이성 항체로, WB 및 ELISA에 적합합니다. HEK293 발현 시스템에서 생산되며, 고순도 Affinity Chromatography로 정제되어 안정적인 연구용 시약입니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0229 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human MERTK (UniProt ID: Q12866) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.75 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849064 |
Product Specific Information
Immunogen sequence:
MGPAPLPLLL GLFLPALWRR AITEAREEAK PYPLFPGPFP GSLQTDHTPL LSLPHASGYQ PALMFSPTQP GRPHTGNVAI PQVTSVESKP LPPLAFKHTV
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. It regulates key physiological processes such as cell survival, migration, differentiation, and efferocytosis. Ligand binding induces autophosphorylation of MERTK, enabling downstream signaling through molecules like GRB2 and PLCG2, and activating MAPK1, MAPK2, FAK/PTK2, and RAC1.
MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and RPE rod outer segment phagocytosis. Additionally, it inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, leading to SOCS1 and SOCS3 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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