Thermo Fisher Scientific CamK4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CaMKIV (residues 400–425). Validated for WB and IP. Supplied as liquid, unconjugated form (0.20 mg/mL). Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunoprecipitation (IP) | 3–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 400 and 425 of human Calcium/Calmodulin-dependent Protein Kinase IV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV plays an important role in synaptic plasticity via gene regulatory effects. In T-cells, this protein contributes to calcium signaling affecting NFAT activity. CaMKIV is encoded, along with calspermin, by the CaMKIV gene and is associated with chromatin in germ cells, suggesting a role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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