Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PerCP-eFluor 710, eBioscience
마우스 CD41 단백질을 인식하는 Rat IgG1 단클론 항체로, PerCP-eFluor 710 형광체로 결합됨. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 혈소판 및 조혈줄기세포 연구에 적합. 488 nm 청색 레이저로 여기, 710 nm에서 방출.
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Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PerCP-eFluor 710
Applications
- Flow Cytometry (Flow)
- Tested dilution: ≤ 0.5 µg/test
- A test is defined as the amount of antibody that stains a cell sample in 100 µL volume (10⁵–10⁸ cells/test).
- Recommended careful titration for optimal performance.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PerCP-eFluor™ 710 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioMWReg30 (MWReg30) |
| Conjugate | PerCP-eFluor™ 710 |
| Excitation / Emission Max | 482 / 708 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10853180 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 510 / 555 / 660-120S
- NovaFluor Yellow 570 / 660
- PE
- PE-Cyanine7
- Super Bright 436 / 600 / 645
- Request custom conjugation
Product Specific Information
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb).
CD41 is expressed on platelets, megakaryocytes, and hematopoietic progenitors. It associates with CD61 (gpIIIa, integrin beta III) forming a receptor involved in platelet adhesion and aggregation.
Studies using SLAM-family markers (CD48, CD150) show that CD150⁺CD48⁻CD41⁻ profile efficiently identifies hematopoietic stem cells (HSCs).
- Reported Application: Flow cytometric analysis
- Tested Application: Flow cytometric analysis of mouse platelets
- Recommended Use: ≤ 0.5 µg/test
Fluorophore Information:
PerCP-eFluor® 710 emits at 710 nm, excited by 488 nm blue laser. Use a 710/50 bandpass filter (695/40 acceptable). Ensure instrument compatibility.
Fixation:
Samples can be stored up to 3 days at 4°C in the dark using:
- IC Fixation Buffer (Product #00-8222)
- 1-step Fix/Lyse Solution (Product #00-5333)
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa α and 23 kDa β) that interact with CD61 in the presence of calcium to form a functional receptor.
It mediates platelet aggregation and binds to von Willebrand factor, fibrinogen, fibronectin, and vitronectin.
Expressed in megakaryocyte-platelet lineage and early hematopoietic stages.
Associated diseases: Glanzmann Thrombasthenia, Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures.
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