Thermo Fisher Scientific MIA3/TANGO Polyclonal Antibody
MIA3/TANGO 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관. 인간 시료에 반응하며 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of human Melanoma inhibitory activity protein 3 (MIA3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
MIA3/TANGO plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms for export from the endoplasmic reticulum. It is essential for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. MIA3 participates in cargo loading at ER exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1.
While specific to COL7A1 cargo loading, it may also assist in secretion of other proteins or lipoproteins in certain cells. Additionally, it is required for proper assembly of COPII coat components and localization of SEC16A and ER-resident complexes (MIA2 and PREB/SEC12) to ER exit sites.
[UniProt references: PubMed 27138255, 19269366, 28442536]
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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