Thermo Fisher Scientific MIA3/TANGO Polyclonal Antibody
Rabbit polyclonal antibody targeting human MIA3/TANGO protein. Validated for Western blot and immunoprecipitation applications. Unconjugated, liquid form, 1 mg/mL concentration. Suitable for studying ER cargo transport and collagen VII secretion mechan...
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Applications
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of human Melanoma inhibitory activity protein 3 (MIA3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MIA3/TANGO plays a role in the transport of large cargos that cannot fit into COPII-coated vesicles. It is essential for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. MIA3 interacts with COPII coat subunits Sec23/24 to guide SH3-bound COL7A1 into carriers at endoplasmic reticulum exit sites (ERES). It is specific to COL7A1 cargo loading but may also assist in secretion of other proteins, including lipoproteins. MIA3 is required for proper assembly of COPII components and localization of SEC16A and ER-resident complexes (MIA2, PREB/SEC12) at ERES.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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