Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), Alexa Fluor 488, eBioscience
인간 CD19 항원에 특이적인 HIB19 단클론 항체로, Alexa Fluor 488 형광 표지되어 Flow Cytometry에 최적화됨. B세포 발달 단계 전반에서 발현되는 CD19 검출에 사용. 5 µL/test로 사전 적정 및 정제된 액상 형태, 연구용으로만 사용.
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Thermo Fisher Scientific CD19 Monoclonal Antibody (HIB19), Alexa Fluor 488, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (1 µg)/test | View 30 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 488 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIB19 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1659679 |
Available Formats
- Unconjugated
- Alexa Fluor 532, 561, 660, 700
- APC, APC-eFluor 780
- Biotin
- Brilliant UV / Violet / Yellow series
- eFluor 450, 506
- FITC
- Functional Grade
- NovaFluor series (Blue, Red, UV, Violet, Yellow)
- PE, PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
- PerCP-Cyanine5.5, PerCP-eFluor 710
- Super Bright series (436–780)
- Custom conjugation available
Product Specific Information
Description:
The HIB19 monoclonal antibody reacts with human CD19, a 95 kDa transmembrane glycoprotein expressed by B cells throughout development except plasma cells. CD19 forms a complex with CD21, CD81, Leu13, and MHC class II, participating in BCR signaling that induces tyrosine phosphorylation, calcium flux, and B cell proliferation.
Applications Reported:
Reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended usage: 5 µL (1 µg) per test in a final volume of 100 µL. Cell number: 10⁵–10⁸ cells/test.
Optical Properties:
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
CD19 is a member of the immunoglobulin superfamily with two Ig-like domains, expressed on all peripheral B cells and certain myeloid leukemia cells. It acts as a co-receptor with BCR, lowering the activation threshold for antigen-dependent stimulation. CD19 regulates B cell proliferation and differentiation, and its mutation or overexpression leads to immunological abnormalities such as hypogammaglobulinemia or B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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