Thermo Fisher Scientific NEDD8 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human NEDD8 protein. Validated for Western blot at 1:500–1:2,000 dilution. Liquid form with 0.47 mg/mL concentration. Suitable for research use in cell cycle and ubiquitination studies. Store at −20°C, avoid freez...
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–81 of human NEDD8 (NP_006147.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.47 mg/mL |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805467 |
Product Specific Information
- Immunogen Sequence: MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK ILGGSVLHLV LALRGGGGLR Q
- Positive Samples: Mouse brain, Rat brain
- Cellular Location: Nucleus
Target Information
NEDD8 is a ubiquitin-like protein that plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires activation by the E1 complex (UBE1C-APPBP1) and linkage to the E2 enzyme (UBE2M). Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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