Thermo Fisher Scientific Phospho-INSR (Tyr1355) Polyclonal Antibody
인간 INSR Tyr1355 인산화 부위를 인식하는 Rabbit Polyclonal Antibody입니다. Western blot과 IHC(Paraffin)에서 사용 가능하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관하며 연구용으로 적합합니다.
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Thermo Fisher Scientific Phospho-INSR (Tyr1355) Polyclonal Antibody
Applications 및 권장 희석 배율
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Insulin Receptor around Tyr1355 phosphorylation site |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553693 |
Product Specific Information
- Detects endogenous protein at a molecular weight of approximately 95 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates insulin signaling. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake.
INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR.
In humans, the INSR gene is located on chromosome 19.
Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may contribute to certain forms of growth retardation.
주의사항
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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