Thermo Fisher Scientific Phospho-c-Cbl (Tyr674) Polyclonal Antibody
Phospho-c-Cbl (Tyr674) 폴리클로날 항체로 인간, 마우스, 랫트 시료에 반응. Western blot 및 IHC(Paraffin)에 사용 가능. 고순도(>95%) 항원 친화 크로마토그래피 정제. PBS/50% 글리세롤 보관, 연구용 전용.
- 카탈로그번호
- PA536735
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Cbl around the phosphorylation site of Tyrosine 674 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553690 |
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 100 and 120 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation.
Cbl-c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells, whereas other Cbl proteins are ubiquitously expressed.
Cbl-c, like other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation.
Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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