Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CEW33D), PE-eFluor 610, eBioscience
인간 CD183(CXCR3)을 인식하는 CEW33D 단클론 항체로, PE-eFluor 610 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 488–561 nm 레이저로 여기됩니다. 염증 및 자가면역 연구에 유용하며, 4°C 암소 보관이 필요합니다.
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- 61-1839-4x (2개 옵션)
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CEW33D), PE-eFluor 610, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.5 µg)/test | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-eFluor™ 610, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CEW33D |
| Conjugate | PE-eFluor™ 610 |
| Excitation/Emission Max | 565/606 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Wet ice |
| RRID | AB_2574588 |
Additional Available Formats
- APC
- Biotin
- Brilliant UV 615
- eFluor 660
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Yellow 690
- PE
- PE-Cyanine7
- Request custom conjugation
Product Specific Information
Description:
The CEW33D monoclonal antibody reacts with human CD183 (CXCR3), a G protein-coupled chemokine receptor that binds CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC). CD183 is associated with type 1 immunity and is upregulated in Th1, CD8 effector, NK, and NKT cells. It mediates infiltration of inflamed tissues in immune responses and inflammatory diseases. Also expressed on some B cells and plasmacytoid dendritic cells.
Applications Reported:
Validated for flow cytometric analysis.
Applications Tested:
Pre-titrated and tested on normal human peripheral blood cells. Use 5 µL (0.5 µg) per test (100 µL final volume). Cell number: 10⁵–10⁸ cells/test.
Fluorophore Information:
PE-eFluor® 610 is excited by 488–561 nm lasers and emits at 607 nm. Recommended filter: 610/20 band pass (equivalent to PE-Texas Red®). Protect from light due to photo-induced oxidation sensitivity.
Fixation:
Samples can be stored in:
- IC Fixation Buffer (Product #00-8222)
- 1-step Fix/Lyse Solution (Product #00-5333)
Store up to 3 days at 4°C in the dark with minimal impact on brightness and FRET efficiency.
Excitation/Emission:
- Excitation: 488–561 nm
- Emission: 607 nm
- Compatible lasers: Blue, Green, Yellow-Green
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
This gene encodes a G protein-coupled receptor selective for chemokines IP10, Mig, and I-TAC, which belong to the CXC subfamily. Binding of these chemokines induces leukocyte trafficking, integrin activation, and chemotaxis. Expression is high in effector/memory T cells and in inflamed tissues. It is a potential therapeutic target for inflammatory diseases. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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