Thermo Fisher Scientific LCK Monoclonal Antibody (LCK-01)
인간 LCK 단백질에 특이적인 Mouse monoclonal antibody로 Western blot, ICC/IF, Flow cytometry, IP 등에 사용 가능. 단백질 A로 정제된 1 mg/mL 액상 형태이며, 4°C에서 보관. 인간 시료에 반응하며 마우스와 교차 반응 없음.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | 1–5 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LCK-01 |
| Immunogen | Peptide corresponding to amino acids 22–36 in the sequence of human Lck |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076445 |
Additional Formats
Product Specific Information
This antibody recognizes a defined epitope (aa 22–36) of Lck, a 56 kDa Src-family protein tyrosine kinase (intracellular antigen).
This antibody does not cross-react with mouse.
Target Information
LCK is a member of the Src-family tyrosine kinases, essential for T-cell receptor (TCR) signaling. Upon TCR activation, LCK phosphorylates ITAM motifs in the zeta subunits, enabling binding of ZAP70, which is subsequently phosphorylated and activated by LCK. Most LCK localizes to the plasma membrane, with some associated with the Golgi apparatus, potentially contributing to Raf activation under weak TCR stimulation.
LCK includes N-terminal myristylation and palmitoylation sites, a PTK domain, and SH2/SH3 domains that mediate protein-protein interactions. It also participates in apoptosis regulation induced by various stimuli, excluding death receptor pathways.
Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants of LCK produce different isoforms of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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