Thermo Fisher Scientific SIRT2 Recombinant Rabbit Monoclonal Antibody (JJ08-83)
Recombinant rabbit monoclonal antibody targeting human SIRT2. Suitable for Western blot applications. Provides high specificity, lot-to-lot consistency, and animal origin-free formulation. Supplied as a liquid at 1 mg/mL, stored at 4°C short term or -2...
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Applications
- Western Blot (WB): 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ08-83 |
| Immunogen | Synthetic peptide within Human SIRT2 aa 1–50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809728 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
SIRT2 (Sirtuin 2) is a NAD-dependent deacetylase (NDAC) involved in gene silencing, cell cycle regulation, and DNA damage repair. It may function as a tumor suppressor in human gliomas and serve as a molecular marker for these cells.
SIRT2 also acts as a redox sensor regulating muscle gene expression in response to nutrient status and exercise. It participates in the phosphorylation cascade during mitosis, being phosphorylated in late G2 phase, M phase, and cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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