Thermo Fisher Scientific TH Monoclonal Antibody (OTI3G3), TrueMAB
Tyrosine Hydroxylase(TH) 단백질을 인식하는 Mouse Monoclonal Antibody로, WB, IHC, ICC/IF에 적용 가능. 고순도 Affinity Chromatography 정제, Human 반응성, 액상 형태로 안정적 저장. 연구용 신경전달물질 합성 관련 효소 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G3 |
| Immunogen | Full length human recombinant protein of human TH produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate enzymatic function. Four human TH mRNA splice variants (hTH1–hTH4) exist, differing in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology. Dysregulation of TH is associated with neurological and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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