Thermo Fisher Scientific TH Monoclonal Antibody (OTI3A7), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:4,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate enzymatic activity.

In humans, four splice variants of TH mRNA (hTH1–hTH4) have been identified. These variants share identical catalytic domains but differ in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in the physiology of adrenergic neurons.

The involvement of TH in catecholamine synthesis suggests its relevance to neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.