Thermo Fisher Scientific TH Monoclonal Antibody (OTI2D4), TrueMAB
Tyrosine Hydroxylase(TH)에 특이적인 단일클론 항체로 인간 시료에 반응. Western Blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 Affinity chromatography 정제 및 안정적인 PBS/BSA/glycerol buffer 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D4 |
| Immunogen | Full length human recombinant protein of human TH produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1–hTH4) have been isolated. These variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. TH is responsible for the conversion of L-tyrosine to L-dopa and plays a key role in the physiology of adrenergic neurons. The role of TH in catecholamine synthesis suggests a correlation between this enzyme and neuropathogenic diseases such as Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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