Thermo Fisher Scientific Human R-Spondin-2 Recombinant Protein, PeproTech
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| 카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
| 120-43-1MG | - | Thermo Fisher Scientific 120-43-1MG Human R-Spondin-2 Recombinant Protein, PeproTech 1 mg pk | 재고문의 | pk | 4,796,000원 | - | 5,275,600원 | |
| 120-43-500UG | - | Thermo Fisher Scientific 120-43-500UG Human R-Spondin-2 Recombinant Protein, PeproTech 500 ug pk | 재고문의 | pk | 2,934,000원 | - | 3,227,400원 | |
| 120-43-250UG | - | Thermo Fisher Scientific 120-43-250UG Human R-Spondin-2 Recombinant Protein, PeproTech 250 ug pk | 재고문의 | pk | 1,776,000원 | - | 1,953,600원 | |
| 120-43-100UG | - | Thermo Fisher Scientific 120-43-100UG Human R-Spondin-2 Recombinant Protein, PeproTech 100 ug pk | 재고문의 | pk | 1,080,000원 | - | 1,188,000원 | |
| 120-43-20UG | - | Thermo Fisher Scientific 120-43-20UG Human R-Spondin-2 Recombinant Protein, PeproTech 20 ug pk | 재고문의 | pk | 311,000원 | - | 342,100원 | |
| 120-43-5UG | - | Thermo Fisher Scientific 120-43-5UG Human R-Spondin-2 Recombinant Protein, PeproTech 5 ug pk | 재고문의 | pk | 139,000원 | - | 152,900원 | |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Functional Assay (Functional)
Assay-dependent
In vitro Assay (IV)
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View 3 publications 3 publications
Product Specifications
Species
Human
Published species
Human, Xenopus
Expression System
CHO cells
Amino acid sequence
ASYVSNPICK GCLSCSKDNG CSRCQQKLFF FLRREGMRQY GECLHSCPSG YYGHRAPDMN RCARCRIENC DSCFSKDFCT KCKVGFYLHR GRCFDECPDG FAPLEETMEC VEGCEVGHWS EWGTCSRNNR TCGFKWGLET RTRQIVKKPV KDTILCPTIA ESRRCKMTMR HCPGGKRTPK AKEKRNKKKK RKLIERAQEQ HSVFLATDRA NQ
Molecular weight
24.4 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
R-Spondin-2 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 for this effect is 0.8 -2.0 ug/ml.
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human R-Spondin-2 is a 24.4 kDa protein consisting of 212 amino acid residues. Due to glycosylation, R-Spondin-2 migrates at an apparent molecular weight of approximately 30.0 kDa by SDS PAGE analysis under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, beta-catenin. This activity effectively activates and increases the subsequent nuclear signaling of beta-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/beta-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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