Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE, eBioscience
마우스 CD41a를 인식하는 단클론 항체로, PE 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, 혈소판 및 조혈전구세포 연구에 유용합니다. 0.125 µg/test 농도로 사용 권장, 4°C 암소 보관.
- 카탈로그번호
- 12-0411-8x (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 3 publications |
| Flow Cytometry (Flow) | 0.125 µg/test | 49 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioMWReg30 (MWReg30) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_763488 |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 510
- NovaFluor Blue 555
- NovaFluor Blue 660-120S
- NovaFluor Yellow 570
- NovaFluor Yellow 660
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). CD41, initially thought to be expressed only on platelets and megakaryocytes, is also found on hematopoietic progenitors in embryos, fetuses, and adults. It associates with CD61 (gpIIIa, integrin beta III) to form a receptor critical for platelet function, mediating binding to fibrinogen, fibronectin, and vitronectin.
Recent studies using SLAM-family markers (CD48, CD150) have shown that CD150+CD48− bone marrow cells efficiently reconstitute hematopoiesis in irradiated mice. The exclusion of CD41+ cells further enhances this efficiency, making CD150+CD48−CD41− a reliable marker profile for hematopoietic stem cells.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse platelets; recommended ≤0.125 µg/test (in 100 µL final volume). Optimal titration recommended per assay.
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) comprises two subunits (120 kDa α and 23 kDa β) that interact with CD61 in the presence of calcium to form a functional adhesive receptor. CD41 mediates platelet aggregation and binds to von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury. It is expressed mainly in the megakaryocyte-platelet lineage and during early hematopoietic differentiation.
Associated Diseases: Glanzmann Thrombasthenia, Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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