Thermo Fisher Scientific GPR68 Polyclonal Antibody
GPR68 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, 액상 형태로 공급됩니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human SPR1 (GPR68, UniProt ID: Q15743-1, antigen range: 208–228, length: 365) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2635282 |
Product Specific Information
This antibody detects endogenous levels of total GPR68 protein.
Target Information
GPR68 (also known as OGR1, ovarian cancer G-protein coupled receptor 1) is a proton-sensing receptor involved in pH homeostasis. It functions as an osteoblastic pH sensor regulating the cellular response to acidosis in bone tissue. GPR68 mediates its action via G proteins that stimulate inositol phosphate (IP) production or Ca²⁺ mobilization. The receptor is nearly inactive at pH 7.8 but fully activated at pH 6.8. It also acts as a tumor suppressor in prostate cancer. Mutations in GPR68 are associated with amelogenesis imperfecta, hypomaturation type 2A6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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