Thermo Fisher Scientific COX15 Polyclonal Antibody

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: MGESWIPEDLF TFSPILRNVF ENPTMVQFD
• Highest antigen sequence identity to orthologs: mouse 90%, rat 93%

Target Information

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, resulting in the production of water.
The mammalian COX apoenzyme is a dimer, each monomer consisting of 13 subunits—some mitochondrial, some nuclear.
COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein belonging to the COX15/ctaA family.
It exists as two alternatively spliced isoforms and is predominantly expressed in tissues with high oxidative phosphorylation rates, such as brain, heart, and muscle.
Defects in COX15 cause Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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