Thermo Fisher Scientific Phospho-NFkB-p65 (Thr435) Polyclonal Antibody
NFkB p65 단백질의 Thr435 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, IP에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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- 500-11864
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
| Immunoprecipitation (IP) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the epitope containing a phosphorylation site Threonine 435 of human NFkB/p65 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: All human tissue
- Cellular location: Nucleus, Cytoplasm
Target Information
Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene located on chromosome 11 in humans. Also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A), it belongs to the Rel family of proteins. NF-kB p65 is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells), which heterodimerizes with subunits p50 or p52. Binding of TNF-alpha to its receptor activates IKK, which phosphorylates I kB, leading to its proteasomal degradation. NF-kB p65 plays a key role in transcription of the immunoglobulin kappa gene in mature B-lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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