Thermo Fisher Scientific SIAH2 Polyclonal Antibody
SIAH2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며, 인간, 마우스, 랫트에 반응합니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용 전용 시약입니다.
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- PA5105291
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SIAH2 (Accession O43255), corresponding to amino acid residues F246–C296 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853884 |
Product Specific Information
This antibody detects endogenous levels of total SIAH2.
Target Information
SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates.
SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina gene, which is essential for the development of the Drosophila R7 photoreceptor.
SIAH-2 targets TRAF2 for degradation under stress conditions such as hypoxia and also mediates degradation of HIF-1 alpha prolyl hydroxylase 3 (PHD3) upon hypoxic exposure.
In hypoxic conditions, SIAH-2 transcription increases, and the protein can modulate TNF-alpha-dependent JNK and NFkB signaling.
SIAH-2 knockout mice display impaired respiratory response and reduced hemoglobin levels under hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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