Thermo Fisher Scientific Phospho-NBS1 (Ser432) Polyclonal Antibody
Phospho-NBS1 (Ser432) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 인산화된 NBS1 단백질 검출에 사용. Western blot, IHC, ICC/IF에 적합. 고순도 정제 및 안정적 PBS/glycerol 버퍼 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NBN (Accession O60934), corresponding to amino acid residues around phosphorylated Ser432 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816841 |
Product Specific Information
This antibody detects endogenous levels of p95/NBS1 only when phosphorylated at Ser432.
Target Information
The p95 gene (identical to NBS1 and nibrin) is part of the hMre11/hRad50 double-strand break complex. This protein complex is associated with Nijmegen breakage syndrome, an autosomal recessive disorder characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity. It plays a key role in linking double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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