Thermo Fisher Scientific TBK1 Polyclonal Antibody
TBK1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. Human, Mouse, Rat 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 NF-kB 신호전달 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | 1:100 | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy-terminus of TBK1/NAK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 174 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981817 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TBK1 (TANK-binding kinase 1) serine/threonine kinase is a member of the IKK family involved in NF-kappa B activation and IRF3 signaling. TBK1 acts as a ubiquitous transcription factor and key mediator of immune and inflammatory gene expression. NF-kB regulates numerous genes in response to extracellular stimuli and is inhibited by IKB proteins in the cytoplasm. Phosphorylation of I-KB by the IKK complex (IKKa, IKKβ, IKKK) leads to its degradation and NF-kB activation. TBK1, also known as NAK or T2K, activates IKKβ through direct phosphorylation and mediates NF-kB activation upon growth factor stimulation. It functions upstream of NIK and the IKK complex and plays a critical role in protecting embryonic liver cells from apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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