Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합. Human 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 보존제 없음. 연구용으로만 사용 가능.
- 카탈로그번호
- PA517490
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding glycine 696 of human IRAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 26.4 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984291 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. This association leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Additionally, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and degradation, and phosphorylate IRF7 to induce its activation and nuclear translocation, resulting in transcriptional activation of type I IFN genes and an antiviral cellular state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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