Thermo Fisher Scientific Human ARMET Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 12 amino acids near the amino terminus of human MANF.
PEP-0549 can be used as a blocking peptide with polyclonal antibody PA5-20432.

Target Information

The protein encoded by this gene is localized in the endoplasmic reticulum and Golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region, but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract.
Polymorphisms in the arginine-rich region, including a specific mutation that changes codon 50 from ATG to AGG, have been reported in various solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.