Thermo Fisher Scientific Human CDNF Synthetic Peptide
휴먼 CDNF 단백질의 카복시 말단 9개 아미노산에 해당하는 합성 펩타이드로, PA5-20429 항체의 블로킹 펩타이드로 사용 가능. 도파민성 뉴런 연구 및 파킨슨병 모델 연구에 활용. 액상 형태, 200 µg/mL 농도, PBS(pH 7.2) 버퍼에 0.1% BSA 포함.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 9 amino acids near the carboxy terminus of human CDNF.
PEP-0546 can be used as a blocking peptide with polyclonal antibody PA5-20429.
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and is highly homologous to the mesencephalic-astrocyte-derived neurotrophic factor.
CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in the brain. Similar to glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease.
Furthermore, CDNF can restore dopaminergic function and prevent degeneration of dopaminergic neurons in the substantia nigra, suggesting potential therapeutic use in Parkinson’s disease.
At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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