Thermo Fisher Scientific Human BRCC3 Synthetic Peptide
인간 BRCC3 단백질의 N-말단 16개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20426과 함께 차단 펩타이드로 사용 가능합니다. BRCC36 단백질 연구 및 DNA 손상 반응 관련 연구에 적합합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PEP0543
- 카테고리
- Esters
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the amino terminus of human BRCC36.
PEP-0543 can be used as a blocking peptide with polyclonal antibody PA5-20426.
Target Information
Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2, as well as RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses ubiquitin E3 ligase activity.
Aberrant levels of BRCC36 were detected in sporadic breast tumors, and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage.
Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors.
At least two isoforms of BRCC36 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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