Thermo Fisher Scientific LRBA Polyclonal Antibody
Rabbit polyclonal antibody targeting human LRBA protein. Validated for Western blot and immunoprecipitation. Supplied as liquid, 1 mg/mL concentration. Recommended storage at 4°C. For research use only.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1125 to 1175 of human LPS-Responsive Vesicle Trafficking, Beach and Anchor Containing (LRBA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The LRBA protein is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The protein associates with protein kinase A and may play a role in directing intracellular vesicles to activated receptor complexes, aiding secretion and/or membrane deposition of immune effector molecules.
Defects in this gene are associated with common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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