Thermo Fisher Scientific NOX2 Monoclonal Antibody (CL5)
NOX2/gp91phox 단백질을 특이적으로 인식하는 Mouse IgG1 단일클론 항체. Western blot에서 1:1,000 희석으로 검증됨. 단백질 G로 정제된 액상 형태로 제공되며, 단기 4°C 보관 및 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific NOX2 Monoclonal Antibody (CL5)
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL5 |
| Immunogen | Partially purified human neutrophil flavocytochrome b (heparin Ultrogellectin affinity purification in octyl glucoside) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539433 |
Product Specific Information
This antibody is specific for NOX2/gp91phox (aa 135–147, DPYSVALSELGDR).
Target Information
Mox1 and the glycoprotein gp91-phox are essential components of the NADPH oxidase complex, which generates superoxide in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells.
The complex includes membrane-bound flavocytochrome subunits (gp91-phox and p22-phox) and cytosolic proteins (p47-phox and p67-phox).
gp91-phox and p22-phox also act as surface O₂ sensors that initiate cellular signaling under hypoxic conditions.
Mox1 and gp91 share identical C-terminal sequences but differ in expression patterns: gp91-phox is found in eosinophils, neutrophils, monocytes, and B-lymphocytes, while Mox1 is mainly expressed in the colon, with low levels in the uterus and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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