Thermo Fisher Scientific Phospho-NFkB p105 (Ser932) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of NF-kappaB p105/p50 only when phosphorylated at Serine 932.

Target Information

NF-kB is a nuclear transcription factor activated by various extracellular and intracellular stimuli such as cytokines, UV radiation, stress, injury, and bacterial or viral products. It regulates key cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50), a 50 kDa functional subunit of NF-kB, belongs to the Rel protein family. Synthesized as a p105 precursor, it contains an N-terminal RHD region with nuclear localization, DNA-binding, and dimerization domains. NFKB1 (p50) forms homodimers or heterodimers with p65 to create the active NF-kB complex, directing nuclear translocation and DNA binding.
Pathological roles of NF-kB have been implicated in AIDS, hematogenic cancer metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.