Thermo Fisher Scientific CDK8 Polyclonal Antibody
CDK8 단백질 인식용 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상 형태이며, 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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- PA5115001
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDK8 (Accession P49336), corresponding to amino acid residues E14–C64 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899637 |
Product Specific Information
Antibody detects endogenous levels of total CDK8.
Target Information
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 belongs to the cyclin-dependent kinase (CDK) family, which plays a critical role in regulating cell cycle progression. The prototype members p34/Cdc2 and Cdk2 function in the later stages of the cycle, while Cdk4 and Cdk6 are involved in the G1 to S phase transition. By analogy with yeast Cdk8, human Cdk8–Cyclin C complex may interact with RNA polymerase, influencing transcriptional mechanisms that lead to cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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