
Thermo Fisher Scientific CD8 Polyclonal Antibody
CD8 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB와 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 기반의 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD8B (Accession P10966), corresponding to amino acid residues D136–S186 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899632 |
Product Specific Information
This antibody detects endogenous levels of total CD8B.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays a critical role in T cell activation and signal transduction. It is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8 is also found on subsets of NK cells, monocytes, and dendritic cells. Upon MHC-I/peptide complex ligation, CD8 recruits Lck kinase, leading to lymphokine production, motility, and activation of cytotoxic T lymphocytes (CTLs), which are essential for pathogen and tumor clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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