Thermo Fisher Scientific p16INK4a Polyclonal Antibody
Human 및 Mouse 시료에서 CDKN2A/p16INK4a 단백질 검출용 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합. Affinity chromatography로 정제된 고순도 항체로 1 mg/mL 농도. 세포주기 조절 및 종양억제 연구에 활용 가능.
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Thermo Fisher Scientific p16INK4a Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDKN2A (Accession P42771), corresponding to amino acid residues M1–Q50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899638 |
Product Specific Information
Antibody detects endogenous levels of total CDKN2A/p16INK4a.
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode isoforms functioning as inhibitors of CDK4 kinase. Another transcript includes an alternate first exon located 20 Kb upstream, containing an alternate open reading frame (ARF) that encodes a structurally unrelated protein. The ARF product stabilizes tumor suppressor protein p53 by interacting with and sequestering MDM2, preventing p53 degradation. Despite structural and functional differences, CDK inhibitor isoforms and the ARF product share a common role in cell cycle G1 control. This gene is frequently mutated or deleted in various tumors and is an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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