Thermo Fisher Scientific PDPK1/PDPK2/PDPK3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing PDPK1/2/3 (PKD family). Validated for Western blot at 1:500–1:1,000 dilution. Detects endogenous protein (90–140 kDa) with >95% purity. Suitable for human, mouse, and rat samples; supplied unconjugated in PBS with...
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Applications
- Western Blot (WB): 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 708–763 of human PKD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553375 |
Product Specific Information
- Detects endogenous protein at molecular weight of 90–140 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC.
Involved in regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, NF-κB activation, cell migration, differentiation, and proliferation via MAPK1/3 (ERK1/2) signaling.
Plays roles in cardiac hypertrophy, VEGFA-induced angiogenesis, apoptosis, and inflammatory responses.
Phosphorylates EGFR and RIN1, modulating downstream signaling and Golgi membrane structure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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