Thermo Fisher Scientific GATA2/GATA3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins.
Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3, an enhancer-binding protein containing a zinc finger domain, is expressed in T cells but not in B cells or macrophages. It is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene and the 5′ end of the mouse gene. The human gene comprises six exons over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1, though no other structural homologies were found.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.