Thermo Fisher Scientific CLEC2D Polyclonal Antibody, MaxPab

Thermo Fisher Scientific CLEC2D Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000
Publications: -

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER KWICSKSDIH V

Target Information

Zhou et al. have identified a protein that inhibits multinucleate osteoclast formation in murine osteoblast and spleen cell co-cultures. This protein, Osteoclast Inhibitory Lectin (OCIL), also inhibits osteoclast formation in spleen cell cultures treated with RANKL and M-CSF.
mOCIL acts directly on macrophage/monocyte cells, showing inhibitory action on adherent spleen cell cultures depleted of stromal and lymphocytic cells. It completely inhibited osteoclast formation during the proliferative phase and resulted in 70% inhibition during the differentiation phase.
OCIL mRNA expression in osteoblasts is enhanced by parathyroid hormone, calcitriol, interleukin-1, IL-11, and retinoic acid. OCIL is expressed in osteoblasts, chondrocytes, and various extraskeletal tissues. Since OCIL expression parallels RANKL distribution, it is suggested that RANKL and OCIL may interact in skeletal and extracellular tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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