Thermo Fisher Scientific CLEC2D Polyclonal Antibody, MaxPab
CLEC2D 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간과 마우스 반응성. PBS 기반 액상 형태, 보존제 없음, -20°C 보관. 연구용으로 사용.
- 카탈로그번호
- H00029121-D01P
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CLEC2D Polyclonal Antibody, MaxPab
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CLEC2D (NP_037401.1, 1 a.a. ~ 191 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER KWICSKSDIH V
Target Information
Zhou et al. have identified a protein that inhibits multinucleate osteoclast formation in murine osteoblast and spleen cell co-cultures. This protein, Osteoclast Inhibitory Lectin (OCIL), also inhibits osteoclast formation in spleen cell cultures treated with RANKL and M-CSF.
mOCIL acts directly on macrophage/monocyte cells, showing inhibitory action on adherent spleen cell cultures depleted of stromal and lymphocytic cells. It completely inhibited osteoclast formation during the proliferative phase and resulted in 70% inhibition during the differentiation phase.
OCIL mRNA expression in osteoblasts is enhanced by parathyroid hormone, calcitriol, interleukin-1, IL-11, and retinoic acid. OCIL is expressed in osteoblasts, chondrocytes, and various extraskeletal tissues. Since OCIL expression parallels RANKL distribution, it is suggested that RANKL and OCIL may interact in skeletal and extracellular tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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