Thermo Fisher Scientific CD274 Monoclonal Antibody (3F4)
인간 PD-L1(CD274)을 인식하는 Mouse IgG2b 단클론 항체. Western blot 및 ELISA에 적합하며, 액상 형태로 제공. PBS(pH 7.4) 저장용액, 방부제 없음. 종양 면역 회피 연구 및 PD-1/PD-L1 신호전달 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F4 |
| Immunogen | CD274 (AAH74984.1, 18 a.a. ~ 238 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AFTVTVPKDL YVVEYGSNMT IECKFPVEKQ LDLAALIVYW EMEDKNIIQF VHGEEDLKVQ HSSYRQRARL LKDQLSLGNA ALQITDVKLQ DAGVYRCMIS YGGADYKRIT VKVNAPYNKI NQRILVVDPV TSEHELTCQA EGYPKAEVIW TSSDHQVLSG KTTTTNSKRE EKLFNVTSTL RINTTTNEIF YCTFRRLDPE ENHTAELVIP ELPLAHPPNE R
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a member of the B7 family.
PD-L1 binds to its receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling.
Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production.
PD-L1 expression is abundant in many murine and human cancers and can be up-regulated by IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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