Thermo Fisher Scientific CD35 Monoclonal Antibody (To5), Biotin
인간 CD35/CR1을 검출하는 Biotin 결합 단일클론 항체로 FACS, IHC(F), WB에 적합. 고순도 Protein G 정제, 안정적 PBS/BSA 버퍼. 다양한 형광 및 비오틴 포맷 제공. 연구용으로 면역복합체 처리 및 보체 결합 연구에 활용 가능.
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Thermo Fisher Scientific CD35 Monoclonal Antibody (To5), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | 0.5 µg/1×10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | To5 |
| Immunogen | Mouse monoclonal antibodies raised against human C3b receptor-enriched precipitates from tonsil cell membranes |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539103 |
Additional Formats
Product Specific Information
MA5-17713 targets CD35/CR1 in FACS, IHC (F), and WB applications and shows reactivity with Human samples.
The immunogen is mouse monoclonal antibodies raised against human C3b receptor-enriched precipitates from tonsil cell membranes.
Target Information
CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein functioning as a receptor for C3b and C4b, key components of the complement system. It mediates cellular binding to particles and immune complexes that have activated complement.
CD35 exists in four allotypes (C, A, B, D) ranging from 160–250 kDa. It is expressed on neutrophils, eosinophils, monocytes, B cells, certain NK cells, erythrocytes, myeloid leukemias, and follicular dendritic reticulum cells, but not on basophils.
Altered expression or mutations in CD35 are linked to gallbladder carcinoma, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, and sarcoidosis. CD35 gene mutations have also been associated with reduced Plasmodium falciparum rosetting, conferring protection against severe malaria.
Alternate splice variants and a secreted form have been described but not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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