Thermo Fisher Scientific CD35 Monoclonal Antibody (To5), APC

Thermo Fisher Scientific CD35 Monoclonal Antibody (To5), APC

Applications

• Flow Cytometry (FACS)

Tested Dilution

• 0.5 µg / 1×10⁶ cells

Species Reactivity

• Human

Host / Isotype

• Mouse / IgG1

Class

• Monoclonal

Type

• Antibody

Clone

• To5

Immunogen

Mouse monoclonal antibodies raised against human C3b receptor-enriched precipitates from tonsil cell membranes.

Conjugate

• APC (Allophycocyanin)

Additional Formats

• Unconjugated (MA5-17711)
• Biotin (MA5-17713)
• FITC (MA5-17714)
• PE (MA5-17715)
• Custom conjugation available upon request

Excitation / Emission Max

• 651 / 660 nm

Form

• Liquid

Concentration

• 0.1 mg/mL

Purification

• Protein G

Storage Buffer

• PBS

Contains

• 0.02% sodium azide

Storage Conditions

• 4°C, do not freeze

Shipping Conditions

• Ambient (domestic)
• Wet ice (international)

RRID

• AB_2539102

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Product Specific Information

MA5-17712 targets CD35/CR1 in FACS applications and shows reactivity with human samples.
The immunogen is mouse monoclonal antibodies raised against human C3b receptor-enriched precipitates from tonsil cell membranes.

Target Information

CD35 (CR1, Complement Receptor 1) is a membrane-bound glycoprotein that functions as the cellular receptor for C3b and C4b, key components of the complement system. It mediates binding and clearance of immune complexes and foreign macromolecules.

CD35 exhibits four allotypes (C, A, B, D) with molecular weights of 160, 190, 220, and 250 kDa, respectively. It is expressed on neutrophils, eosinophils, monocytes, B-cells, certain NK-cells, erythrocytes, myeloid leukemias, and follicular dendritic cells, but not on basophils.

Reduced CD35 expression or gene mutations have been linked to gallbladder carcinoma, glomerulonephritis, lupus, and sarcoidosis. Mutations may also reduce Plasmodium falciparum rosetting, providing protection against severe malaria. Alternate splice variants and a secreted form have been reported but are not fully characterized.

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For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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