Thermo Fisher Scientific CD217 (IL-17Ra) Monoclonal Antibody (424LTS), APC, eBioscience
인간 IL-17RA를 인식하는 424LTS 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. APC 형광표지로 651/660 nm 파장에서 검출되며, 염증 반응 연구 및 IL-17 관련 신호전달 분석에 적합합니다. 4°C 암소 보관, 동결 금지.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD217 (IL-17Ra) Monoclonal Antibody (424LTS), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 424LTS |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10597595 |
Available Formats
Product Specific Information
Description:
The 424LTS monoclonal antibody reacts with and blocks IL-17A binding to human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein (~96 kDa, 866 amino acids) involved in inflammatory responses to IL-17A, IL-17F, and IL-17AF heterodimer. It forms heterodimeric complexes with other receptor family members, including IL-17RC for IL-17A/F and IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, with elevated expression on granulocytes and monocytes in leukocytes.
Applications Reported:
This 424LTS antibody has been reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells.
Recommended use: 5 µL (0.25 µg) per test (in 100 µL final volume).
Applicable cell number: 10⁵–10⁸ cells/test (empirically determined).
Excitation/Emission: 633–647 nm / 660 nm (Red Laser)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes and induces maturation of CD34⁺ hematopoietic precursors into neutrophils. IL-17RA is a type I membrane glycoprotein that binds IL-17A and IL-17F with low affinity. IL-17A and its receptor are implicated in inflammatory and autoimmune diseases such as rheumatoid arthritis.
Defects in IL-17RA cause familial candidiasis type 5 (CANDF5), a rare disorder with altered immune responses and impaired fungal clearance.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.