Thermo Fisher Scientific POLR3G Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 POLR3G 단백질 검출용 Rabbit Polyclonal Antibody. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. PBS 및 50% glycerol 저장용액, 4°C 단기/−20°C 장기 보관. 연구용으로만 사용.
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Thermo Fisher Scientific POLR3G Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human POLR3G |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719455 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates.
POLR3G is a specific peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs.
It may interact with other members of the RPC3/POLR3C–RPC6/POLR3F–RPC7/POLR3G subcomplex to bind RNA Pol III to the TFIIIB–DNA complex.
POLR3G plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in innate immune response.
It can sense non-self dsDNA and transcribe it into dsRNA, which induces type I interferon and NF-κB activation through the RIG-I pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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