Thermo Fisher Scientific GLI2 Polyclonal Antibody
GLI2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ELISA, IP에 적합합니다. 인간 및 침팬지 반응성이 있으며, Affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| ELISA | 1:10,000–1:30,000 |
| Immunoprecipitation (IP) | 1:500–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chimpanzee, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 30–65 of human Gli-2 (isoform a). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human Gli-2 protein. A BLAST analysis suggests cross-reactivity with Gli-2 from human and chimpanzee based on the immunizing sequence.
Target Information
Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are transcription factors that bind DNA through zinc finger motifs containing conserved H-C links. Gli family zinc finger proteins mediate Sonic hedgehog (Shh) signaling and are implicated as potent oncogenes in embryonal carcinoma cells. The encoded protein localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis and is associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, and various forms of polydactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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